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| News Release |
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Information in the news releases is current on the date of the announcement, but is subject to change without prior notice. |
| 2003 Release |
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| December 22, 2003 |  |
Eisai Submits MAA for New Formulation of ARICEPT (donepezil hydrochloride), Rapid Disintegration Tablet in the European Union

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| December 18, 2003 |  |
Eisai Submits NDAs for New Formulations of ARICEPT (donepezil hydrochloride), Rapid Disintegration Tablet and Liquid Formulation in the U.S.

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| December 15, 2003 |  |
Eisai Submits PARIET (rabeprazole sodium) for Zollinger-Ellison Syndrome and Other Pathological Hypersecretory Conditions in the European Union

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| November 21, 2003 |  |
Eisai Commences US Legal Action Over Aciphex ANDA Filings

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| November 13, 2003 |  |
Notice of Conclusion of License Agreement Regarding Research Information of Lung Cancer Gene

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| November 10, 2003 |  |
Eisai Launches Natural Vitamin E Capsule, JUVELUX E PURE

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| November 5, 2003 |  |
Notice Concerning Food Additives and Chemicals Division to be split off into a Newly Incorporated Subsidiary

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| November 5, 2003 |  |
Notice Concerning Dissolution of Subsidiary

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| October 22, 2003 |  |
Voluntary Product Recall of SKAINAR ANTITUSSIVE & EXPECTORANT

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| September 24, 2003 |  |
Toyama Chemical and Eisai Announce NDA submission to the Ministry of Health, Labour and Welfare

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| September 18, 2003 |  |
Eisai Launches SKAINAR S TABLETS FOR RHINITIS Containing Pseudoephedrine Hydrochloride for Nasal Congestion

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| September 16, 2003 |  |
Eisai Submits Application for PARIET (rabeprazole sodium) for the On-Demand Therapy of Symptomatic GORD in the European Union

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| September 12, 2003 |  |
Eisai Launches MAXALT 10 mg Tablet, MAXALT RPD 10 mg Tablet , 5-HT1B/1D Receptor Agonist-Type Migraine Treatment Agents

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| September 9, 2003 |  |
Teva Pharmaceutical Industries Announces NDA Submission for Parkinson's Disease Treatment

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| September 3, 2003 |  |
Notice Concerning the Exemption from the Substitutional Portion of Eisai's Welfare Pension Fund

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| August 19, 2003 |  |
Eisai Launches NABOLIN S, a Mecobalamin (Activated Vitamin B12) Tablet

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| July 30, 2003 |  |
Partial Amendment of the Marketing Alliance Agreement for the Migraine Treatment MAXALT 

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| July 30, 2003 |  |
Food Additives and Chemicals Division to be placed into Subsidiary Company

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| July 18, 2003 |  |
PARIET 10 mg Receives Approval for Maintenance Therapy for Gastroesophageal Reflux Disease

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| July 4, 2003 |  |
Non-Approvable Letter Received from FDA for ARICEPT for VaD Treatment Indication

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| July 1, 2003 |  |
Notice Concerning Stock Options Including the Amount to Be Paid for the Exercise of Stock Options

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| June 24, 2003 |  |
Notice of Allotment of Stock Options

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| June 23, 2003 |  |
Eisai Launches Activated Vitamin B2 Tablet, CHOCOLA BB PLUS

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| May 26, 2003 |  |
Eisai Submits sNDA for CLEACTOR for Acute Pulmonary Embolism

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| May 15, 2003 |  |
Teva and Eisai Sign Agreement for Co-Development of Rasagiline for Alzheimer's Disease, and Co-Promotion for Parkinson's Disease, in the U.S.

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| May 13, 2003 |  |
Notice on Providing Stock Options in the Form of New Stock Issuance

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| May 13, 2003 |  |
Notice Concerning Acquisition of the Company's Own Shares in the Market

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| February 26, 2003 |  |
Kyorin and Eisai Form an Alliance on Marketing of "rizatriptan benzoate" (generic name), an agent for migraine

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| February 25, 2003 |  |
Sanko Junyaku Co., Ltd., Eisai Co., Ltd. and FUJIREBIO INC. Conclude Joint Research Agreement for DCP Test Kit for Hepatocellular Carcinoma (HCC)

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| February 24, 2003 |  |
Eisai Co., Ltd. Establishes 'Neuroscience for Drug Discovery Research' Program at Kyoto University

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| February 24, 2003 |  |
CHOCOLA FE CARE, A 50ml Bottle Iron and Medicinal Herb Extract Drink

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| February 6, 2003 |  |
Eisai Co., Ltd. Starts SKAINAR Pollen Information Service

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| February 3, 2003 |  |
E7155, MRI Contrast Agent Application Withdrawn in Japan

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| January 15, 2003 |  |
Eisai Co., Ltd. and Mitsui Knowledge Industry Co., Ltd. Conclude Comprehensive Mutual Cooperation Agreement

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| January 14, 2003 |  |
Eisai Co., Ltd. Announces U.S. Subsidiary, Eisai Inc., to Increase Pharmaceutical Sales Force by 60 Percent

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| January 7, 2003 |  |
Eisai Inc., a U.S. Subsidiary of Eisai Co., Ltd. Assumes All Distribution Responsibilities for ARICEPT 

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