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| News Release |
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Information in the news releases is current on the date of the announcement, but is subject to change without prior notice. |
| 2004 Release |
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| December 17, 2004 |
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Eisai Recieves A Positive Opinion for Zonegran Marketing Authorization From European Committee For Medicinal Products for Human Use (CHMP)

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| November 19, 2004 |
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Notice Concerning Completion of the Acquisition of the Company's Own Shares through ToSTNeT-2

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| November 18, 2004 |
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Notice Concerning the Acquisition of the Company's Own Shares through ToSTNeT-2

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| November 15, 2004 |
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Eisai In-licenses Anti-hepatitis B Agent clevudine From Bukwang Pharm (South Korea)

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| October 29, 2004 |
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Eisai Reacquires Worldwide Rights for a Triazole-Type Anti-Fungal Agent

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| October 29, 2004 |
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Eisai Announces Establishment of its Pharmaceuticals Marketing Subsidiary in India

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| October 28, 2004 |
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Eisai Announces Establishment of its European Regional Headquarters (Holding Company) in the U.K.

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| October 22, 2004 |
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Eisai Receives Approvals for New Formulations of ARICEPT (donepezil hydrochloride), Orally Disintegrating Tablet and Liquid Formulation in the U.S.

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| August 27, 2004 |
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Notice Concerning the Revision of Eisai Co., Ltd. and Consolidated Subsidiaries Quarterly Financial Report for the Period Ended June 30, 2004

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| August 5, 2004 |
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Eisai Launches SAHNE WHITE , A Medicated Skin Cream that Provides Protection Against Spots and Produces Smooth Skin

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| July 30, 2004 |
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Eisai's German Pharmaceuticals Marketing Subsidiary Starts Promotion of AstraZeneca's ENTOCORT , a locally acting Glucocorticosteroid for Inflammatory Bowel Diseases

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| July 30, 2004 |
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Notice Concerning Acquisition of the Company's Own Shares

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| July 8, 2004 |
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Eisai Receives European Marketing Authorization for PARIET (rabeprazole sodium) for Zollinger-Ellison Syndrome

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| July 1, 2004 |
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Notice Concerning Stock Options (Stock Acquisition Rights) Including the Amount Paid In Upon the Exercise of Stock Options

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| June 30, 2004 |
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Eisai Launches the First Treatment in Japan for Apnea of Prematurity Low Concentration Aminophylline, APNISSION Injection 15mg

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| June 28, 2004 |
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Eisai's Statement to AD2000 Clinical Trial Led By the Collaborative Group of University of Birmingham

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| June 28, 2004 |
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Eisai Launches New Formulation of ARICEPT , Rapid Disintegration Tablet, in Japan

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| June 24, 2004 |
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Notice on Allotment of Stock Options (Stock Acquisition Rights)

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| June 18, 2004 |
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Sanko Junyaku Co., Ltd., Subsidiary of Eisai Co., Ltd., to Launch New DCP Diagnostic Test Kit for Hepatocellular Carcinoma (HCC), LUMIPULSE PIVKA-II EISAI

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| May 31, 2004 |
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Eisai Submits MAA for New Formulation of ARICEPT (donepezil hydrochloride), Liquid Formulation in the European Union

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| May 12, 2004 |  |
Eisai Launches SACLON & SACLON Tablets with Increased Ingredients for Restoration of Damaged Stomach Mucosa and Acid Neutralization

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| May 11, 2004 |  |
Notice on Providing Stock Options in the Form of New Stock Issuance

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| May 11, 2004 |  |
Notice Concerning the Spin off of the Machinery Division of Eisai Co., Ltd

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| May 7, 2004 |  |
Amendment of the Co-Development, Licensing and Supply Agreement for the Obesity Management Agent KES524

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| April 23, 2004 |  |
ARICEPT Application for Vascular Dementia is Withdrawn in the European Union

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| April 21, 2004 |  |
PARIET (rabeprazole sodium) Approved for On-Demand Therapy of Symptomatic GORD in the European Union

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| April 19, 2004 |  |
Eisai Launches MENTEC HERB for Irritation-Associated Fatigue and Headache

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| April 2, 2004 |  |
Eisai's German Pharmaceuticals Marketing Subsidiary and GlaxoSmithKline Sign a Promotion Agreement for IMUREK , an Immunosuppressant

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| March 31, 2004 |  |
Eisai acquires anti-epileptic drug Zonegran (zonisamide) from Elan in North America and Europe

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| March 1, 2004 |  |
Eisai Launches CHOCOLA BB DRINK II, A New Vitamin B2 Drink for Alleviation of Skin Roughness

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| February 25, 2004 |  |
Announcement on the Adoption of "Company with Committees System"

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| February 25, 2004 |  |
Integration and Reorganization of Eisai's Machinery Operations

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| February 10, 2004 |  |
E2000, Transdermal Muscle Relaxant Application Withdrawn in Japan

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| February 9, 2004 |  |
Eisai Announces In-Licensing Agreement with Novartis for Rufinamide, A New Antiepileptic Agent

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| February 3, 2004 |  |
Notice Concerning Completion of the Acquisition of the Company's Own Shares through ToSTNeT-2

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| February 2, 2004 |  |
Notice Concerning the Acquisition of the Company's Own Shares through ToSTNeT-2

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| January 30, 2004 |  |
Eisai Commences Another US Legal Action Over Aciphex ANDA Filing

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| January 15, 2004 |  |
Eisai Launches JUSTAT Family of Products, Athlete's Foot and Ringworm Treatments

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| January 7, 2004 |  |
Eisai Inc., a U.S. Subsidiary of Eisai Co., Ltd., Assumes All Distribution Responsibilities for ACIPHEX 

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