Information in the news releases is current on the date of the announcement, but is subject to change without prior notice. |
| 2005 Release |
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| December 27, 2005 |
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Eisai Receives confirmation that Aricept (donepezil hydrochloride), Orodispersible Tablet has successfully completed the Mutual Recognition Procedure in the 12 EU countries

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| December 26, 2005 |
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New Drug Application for Rheumatoid Arthritis Drug Adalimumab (D2E7) Submitted in Japan

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| December 22, 2005 |
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Eisai applies for a new indication of Severe Alzheimer's disease for Aricept (donepezil hydrochloride) in Japan

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| December 19, 2005 |
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Eisai Resubmits the sNDA Application for Aricept for Treatment of Severe Alzheimer's Disease

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| December 12, 2005 |
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Eisai Presented Phase II Data on E7389, a Potential New Therapy for the treatment of Breast Cancer, in US Conference

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| December 8, 2005 |
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Eisai Commences U.S. Legal Action over Aricept ANDA Filing

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| November 29, 2005 |
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Part of a news report on cash dividends of Eisai Co., Ltd.

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| November 25, 2005 |
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Termination of Marketing Alliance on Rulid Tablets 150mg

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| November 18, 2005 |
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Eisai Resubmits NDA Application for the Anti-epilepsy Drug Rufinamide

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| November 1, 2005 |
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SELBELLE Tablets Launched by Eisai Medication that Improves Stomach Function by Protecting Gastric Mucosa from Stomach Acid

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| October 28, 2005 |
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Eisai Announces About the sNDA Application for ARICEPT for Treatment of Severe Alzheimer's Disease

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| October 28, 2005 |
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Eisai Licenses E6020 Vaccine Adjuvant to Sanofi Pasteur SA

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| October 11, 2005 |
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Eisai and TorreyPines Therapeutics Enter Into a New Alliance Contract Regarding a New Genetic Research Program for Alzheimer's Disease

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| September 29, 2005 |
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Dainippon and Eisai Signed Licensing Agreement for A Potential New Treatment for Diabetic Neuropathy

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| September 28, 2005 |
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Eisai Announces Exclusive In-License of All U.S. Promotional Rights for FRAGMIN , an Injectable Anti-Clotting Agent

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| September 22, 2005 |
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Lost Hard Disk Drive Containing Personal Information in Japan

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| September 13, 2005 |
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Eisai Submits New Drug Application for the Anti-epileptic Agent Rufinamide in the United States

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| September 12, 2005 |
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Notice Concerning The Change of The Distribution Company from Aventis Pharma to Eisai for “Actonel 2.5mg Tablets” of Ajinomoto

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| September 1, 2005 |
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Eisai Submitted Application to FDA for ARICEPT for Treatment of Severe Alzheimer's Disease

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| August 29, 2005 |
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Eisai Announces Successful Results in a Phase II Study of E5564 (eritoran) for Treatment of Severe Sepsis

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| August 26, 2005 |
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Eisai Announces Strategic Alliance With BioArctic Neuroscience To Develop Immunotherapy For Alzheimer's Disease

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| August 24, 2005 |
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Sanko Junyaku and Eisai Initiate Co-promoting Yamasa Corporation's Diagnostic Kit for Interstitial Pneumonia, SP-D EIA KIT YAMASA

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| August 22, 2005 |
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Eisai Launches Antiasthmatic, Antitussive and Expectorant, ASTHPHYLLIN S Tablets

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| August 2, 2005 |
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Eisai Receives Approval for Cleactor Inj for Acute Pulmonary Embolism in Japan

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| July 14, 2005 |
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Eisai Announces Establishment of a Pharmaceuticals Marketing Subsidiary in Sweden

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| July 1, 2005 |
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Notice Concerning Stock Options (Stock Acquisition Rights) Including the Amount Paid In Upon the Exercise of Stock Options

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| June 27, 2005 |
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Eisai Announces Launch of Zonegran (zonisamide), Treatment For Epilepsy In the U.K. and Germany

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| June 24, 2005 |
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Notice on Allotment of Stock Options (Stock Acquisition Rights)

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| June 9, 2005 |
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Eisai Announces Establishment of its Pharmaceuticals Marketing Subsidiary in Switzerland

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| May 30, 2005 |
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Concerning Theft of a Computer of Eisai's Subsidiary Sanko Junyaku Containing Personal Information

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| May 24, 2005 |
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Eisai Receives Marketing Authorization Approval for Aricept Evess (donepezil hydrochloride), Orodispersible Tablet in the U.K.

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| May 16, 2005 |
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Notice on Providing Stock Options in the Form of New Stock Issuance

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| April 11, 2005 |
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Eisai and Abbott Signed a Joint Development Agreement for new indication, psoriasis, of anti-rheumatic agent D2E7 (adalimumab)

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| April 1, 2005 |
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Eisai Announces the Merger of Two Subsidiaries in Taiwan

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| March 30, 2005 |
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Eisai Announces Submission of Marketing Authorization Application of the Anti-epileptic Agent Inovelon in Europe

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| March 29, 2005 |
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Dainippon Pharmaceutical and Eisai Conclude Agreement for the Development, Manufacture and Marketing of the Anti-Epileptic Agent Zonisamide in Asia

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| March 24, 2005 |
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Eisai files Lawsuits against Companies Selling Generic Products of Eisai's Selbex Capsule 50 mg based on the Unfair Competition Prevention Law in the Japanese Market

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| March 18, 2005 |
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Eisai and TorreyPines Therapeutics Announces Second Major Discovery Alliance

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| March 16, 2005 |
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Eisai Receives Zonegran Marketing Authorization Granted by European Commission

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| March 15, 2005 |
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Eisai Files Application for A New Indication for PARIET (rabeprazole sodium) in Japan for H. Pylori Eradication Indication

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| February 25, 2005 |
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Eisai Announces the Intermediate Analysis of Anti-osteoporosis Treatment Post-marketing Research to Investigate the Benefits of Menatetrenone As Part of the Ministry of Health, Labour and Welfare's Pharmacoepidemiological Drug Review Program

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| February 25, 2005 |
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US FDA Tentative Approval for ANDA filing of Donepezil Hydrochloride

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| February 24, 2005 |
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Eisai Announces Establishment of its Pharmaceuticals Marketing Subsidiary in Italy

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| February 2, 2005 |
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Notice Concerning Revision of Year End Dividend Forecast For Fiscal Year Period (93rd Company Fiscal Period) Ending March 2005

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| February 2, 2005 |
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Transfer of Marketing Rights of ACE Inhibitor Inhibace from Eisai to Chugai

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| January 18, 2005 |
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ACIPHEX / PARIET Expanded Manufacturing Facility Completed at Misato Plant

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