Information in the news releases is current on the date of the announcement, but is subject to change without prior notice. |
| 2008 Release |
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| December 15, 2008 |
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FDA Approves Sedative-Hypnotic Agent LUSEDRA™ Injection

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| November 17, 2008 |
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FDA Approves BANZEL™ (rufinamide) as Adjunctive Treatment for Lennox-Gastaut Syndrome

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| November 11, 2008 |
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Eisai Completes Alliance Agreement with TorreyPines Therapeutics for Genetic Research Programs to Discover Genes Associated with LOAD
-New Agreement Signed for Eisai to Purchase Research Assets-

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| October 29, 2008 |
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HOUSE OF LORDS REFUSES TO HEAR NICE'S APPEAL

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| October 16, 2008 |
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FDA Grants Full Approval to ONTAK® (denileukin diftitox) For Use in Patients with Cutaneous T-Cell Lymphoma (CTCL)

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| October 8, 2008 |
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Eisai Introduces “Chocola BB® Drink bit”, New Pharmaceutical Drink for Acne and Skin Care

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| September 3, 2008 |
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Eisai Introduces “Hotmin®” for Improving Peripheral Blood Circulation

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| August 24, 2008 |
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FDA Approves ALOXI® (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting

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| August 18, 2008 |
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SymBio Pharmaceuticals and Eisai Sign License Agreement for bendamustine hydrochloride (SyB L-0501)

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| July 31, 2008 |
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Continuation of Policy for Protection of the Company's Corporate Value and Common Interests of Shareholders

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| July 30, 2008 |
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Eisai China Inc. Signs License Agreement in China for -Lipon 300 STADA® for Diabetic Neuropathic Pain

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| July 26, 2008 |
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Eisai Receives Action Letter on Fospropofol Disodium Injection for Sedation in Diagnostic or Therapeutic Procedures -FDA's Not Approvable Letter Outlines Pathway to Potential Approval-

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| July 22, 2008 |
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U.S. FEDERAL CIRCUIT COURT OF APPEALS FULLY UPHOLDS EISAI'S FAVORABLE RULING IN ACIPHEX® PATENT INFRINGEMENT LAWSUIT AGAINST TEVA PHARMACEUTICALS AND DR. REDDY'S LABORATORIES

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| July 16, 2008 |
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Antiosteoporotic drugs “Actonel® 17.5 mg tablets” and “Benet® 17.5 mg tablets” received approval for additional indication in patients with Paget's disease of bone: Both come in new packages.

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| July 9, 2008 |
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ALOXI® (PALONOSETRON HCL) INJECTION AVAILABLE FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING

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| July 7, 2008 |
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Notice on Determination of Details of Stock Options (Stock Acquisition Rights) to be Allocated

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| July 1, 2008 |
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EISAI PROVIDES PRELIMINARY EFFICACY UPDATE ON EORTC PHASE III TRIAL OF DACOGEN® VERSUS SUPPORTIVE CARE IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES

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| July 1, 2008 |
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Proton Pump Inhibitor ACIPHEX® 20 mg Receives Approval for Short-Term Treatment of GERD in Adolescents in United States

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| June 20, 2008 |
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Notice on Allocation of Stock Options (Stock Acquisition Rights)

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| June 19, 2008 |
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Transfer of Subsidiary Stock

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| June 17, 2008 |
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HUMIRA® Subcutaneous Injection 40mg Syringe 0.8mL Now Available for the Treatment of Rheumatoid Arthritis

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| May 29, 2008 |
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Notification with Respect to Issuance of Unsecured Straight Bonds

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| May 29, 2008 |
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Termination of marketing alliance of Breathe Right® nasal strips

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| May 22, 2008 |
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NON-IONIC CONTRAST AGENTS, IOMERON® 350 AND IOMERON® 350 SYRINGE, RECEIVE APPROVAL FOR USE IN DYNAMIC CT LIVER IMAGING

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| May 16, 2008 |
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E7389 Demonstrated Anti-tumor Activity in Heavily Pretreated Patients with Advanced Breast Cancer

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| May 16, 2008 |
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Eisai Presents 16 Papers Accepted for ASCO Annual Meeting Reporting the Latest Results from its Oncology Research

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| May 14, 2008 |
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Notice on New Stock Issuance in the Form of Stock Options

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| May 12, 2008 |
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Distribution of Ethical Drugs Bufferin 81mg Tablets & Bufferin 330mg Tablets

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| May 9, 2008 |
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COURT OF APPEAL MAKES DECISION FOLLOWING RULING THAT NICE PROCESS ON ANTI-DEMENTIA MEDICINES UNFAIR

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| May 8, 2008 |
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FDA ADVISORY COMMITTEE VOTES IN FAVOR OF APPROVAL OF FOSPROPOFOL DISODIUM INJECTION FOR SEDATION

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| May 7, 2008 |
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Eisai Establishes a New Subsidiary in China for Marketing Support and Maintenance of Pharmaceutical Manufacturing Machinery

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| May 1, 2008 |
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Eisai Gained Favourable Ruling by Court of Appeal, as NICE Process for Developing Guidance on Anti-dementia Medicines Ruled Unfair

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| April 24, 2008 |
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Eisai Introduces “Chocola BB® Royal 2” Vitamin B2 Drink for Extreme Fatigue A New Drink with Amino Acids and Reduced Calories

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| April 21, 2008 |
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Notice of Revised Business Forecast for Fiscal Year Ended March 31, 2008, as a Result of Acquisition of MGI PHARMA, INC.

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| April 16, 2008 |
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European Regulatory Agency Grants Orphan Status to Morphotek®'s FARLETUZUMAB (MORAb-003) and MORAb-009

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| April 16, 2008 |
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HUMIRA® received approval for the treatment of rheumatoid arthritis in Japan

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| April 11, 2008 |
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Status of the E2007 (perampanel) Development Program- Termination of Parkinson's Disease Clinical Development and Focus on Neuropathic Pain and Epilepsy Indications -

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| April 3, 2008 |
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Eisai to Resume Clinical Study to Evaluate E2012 as a Potential Next Generation Alzheimer's Disease Treatment

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| March 29, 2008 |
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Eisai is Granted Favorable Preliminary Injunction Ruling in Aricept® Patent Infringement Lawsuit against Teva Pharmaceuticals

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| March 28, 2008 |
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Notice Concerning Shelf Registration for Issuance of Stock Options

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| March 28, 2008 |
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Notice Concerning Shelf Registration for Issuance of Straight Bonds

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| March 14, 2008 |
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Eisai Submits Application for Aricept® Oral Jelly Formulation in Japan

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| March 13, 2008 |
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Eisai and Sanko Junyaku introduce New KL-6 Test Kits for LUMIPULS® Systems for Detecting Marker of Interstitial Pneumonia

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| March 12, 2008 |
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M’s Science and Eisai Sign Option Agreement for Sigma Agonist SA4503

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| March 3, 2008 |
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FDA APPROVES ALOXI® (PALONOSETRON HCL) INJECTION FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING

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| March 3, 2008 |
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Vasolan® (Ischaemic Heart Disease Treatment) Received Approval for Atrial Fibrillation/Flutter and Paroxysmal Supraventricular Tachycardia

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| March 1, 2008 |
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FDA Grants Priority Review for ACIPHEX® sNDA for Short-Term Treatment of GERD in Adolescents

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| February 28, 2008 |
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Eisai Launches New CHOCOLA BB Product Lines CHOCOLA® BB Lucent C and CHOCOLA® BB Lucent Cream for Blemishes and Brown Spots on Skin

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| February 13, 2008 |
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Eisai and Accenture launch Clinical Data Management in India under global outsourcing agreement

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| February 1, 2008 |
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Eisai Announces Change in U.S. Submission Schedule for E7389 New Drug Application

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| February 1, 2008 |
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Eisai Decides Additional Study for Pariet® for New Indication of Non-Erosive Gastro-Esophageal Reflux Disease in Japan

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| January 29, 2008 |
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Abbott and Eisai Finalize License Agreement in Japan for Additional Indications for Adalimumab, The Only Fully Human Monoclonal anti-TNF- Antibody

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| January 29, 2008 |
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EISAI COMPLETES ACQUISITION OF MGI PHARMA

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| January 28, 2008 |
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Abbott and Eisai Announce Changes in the Sales Scheme in Japan for Adalimumab, A Fully Human Monoclonal Anti-TNF- Antibody

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| January 23, 2008 |
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EISAI ANNOUNCES SATISFACTION OF CONDITIONS TO TENDER OFFER FOR MGI PHARMA SHARES

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